| 產(chǎn)品編號(hào) | bs-0820R |
| 英文名稱 | EBNA 3A Rabbit pAb |
| 中文名稱 | EB病毒核抗原-3A抗體 |
| 別 名 | nuclear antigen EBNA-3; Epstein-Barr nuclear antigen 3; EBV nuclear antigen 3; EBNA-3; Epstein-Barr nuclear antigen 3A; EBV nuclear antigen 3A; EBNA-3A; Epstein Barr Virus; EBV-NA3; EBNA3_EBVG. |
| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)菌及病毒 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: EBV/HHV4) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 103 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human herpesvirus 4 EBNA 3A: 301-400/935 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
EBNA3A is a latent viral nuclear protein expressed in Epstein Barr Virus (EBV) transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA3A functions as a transcriptional regulator though the target genes are currently unknown.
Function: Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop. Subunit: Interacts with human UCKL1. Interacts with host CTPB1; this interaction seems important for EBNA3-mediated transcriptional repression. Interacts with host RBPJ. Subcellular Location: Host nucleus matrix. Note=Associated with the nuclear matrix. Similarity: Belongs to the herpesviridae EBNA-3 family. Database links: SwissProt: Q3KST2 HHV-4 Entrez Gene: 3783762 HHV-4
EB病毒核抗原-3（nuclear antigen EBNA-3）是EB病毒編碼核蛋白，位于細(xì)胞核的新的酶聚合體，主要作為轉(zhuǎn)錄調(diào)節(jié)因子，指導(dǎo)蛋白與蛋白之間相互作用，為核糖核苷酸補(bǔ)救途徑的一部分. |
