產(chǎn)品編號 | bs-0413R |
英文名稱 | MMP3 Rabbit pAb |
中文名稱 | 基質(zhì)金屬蛋白酶3抗體 |
別 名 | MMP3_HUMAN; Stromelysin-1; EC:3.4.24.17; STMY1; SL-1; SL 1; SL1; Matrix metalloproteinase-3(MMP-3); MMP-3; MMP 3; Transin-1; |
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Specific References (23) | bs-0413R has been referenced in 23 publications.
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研究領域 | 腫瘤 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | Human |
產(chǎn)品應用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 42/52 kDa |
檢測分子量 | |
細胞定位 | 細胞外基質(zhì) 分泌型蛋白 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human MMP3: 401-477/477 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. SWISS: P08254 Gene ID: 4314 Database links: Entrez Gene: 4314 Human Entrez Gene: 17392 Mouse Omim: 185250 Human SwissProt: P08254 Human SwissProt: P28862 Mouse Unigene: 375129 Human 合成與降解(Synthesis and Degradation)
基質(zhì)金屬蛋白酶(matrix metalloproteinases, MMPs)是一族依賴鋅離子而降解各種細胞外基質(zhì)的蛋白酶,亦稱IV型膠原酶或稱明膠酶A,其主要功能為降解IV型膠原,因而它在腫瘤細胞突破基底膜屏障和浸潤轉移中起重要作用。 |
產(chǎn)品圖片 | |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關于肽鏈的設計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |
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