| 產(chǎn)品編號(hào) | bs-0770R |
| 英文名稱(chēng) | SFTPA1 Rabbit pAb |
| 中文名稱(chēng) | 肺表面活性蛋白A抗體 |
| 別 名 | SP-A; SFTPA2; SFTPA1; Surfactant Protein A; pulmonary surfactant-associated glycoprotein A; Pulmonary surfactant-associated protein A2 precursor; SP-A1; SP-A2; SP-A; PSP-A; PSPA; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; MGC133365; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein; SFTP1; SFTPA; SFTPA1B; SP A; SP A1; Surfactant pulmonary associated protein A1; PSPA; SPA2; SFTP1; SPAII; COLEC5; SFTPA2B; SFTA1_HUMAN; SFPA2_HUMAN; Pulmonary surfactant-associated protein A1; Pulmonary surfactant-associated protein A2. |
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Specific References (3) | bs-0770R has been referenced in 3 publications.
[IF=3.061] Fang?Q et al. pre-B cell colony enhancing factor negatively regulates Na and fluid transport in lung epithelial cells. Am J Transl Res. 2018 Jul 15;10(7):2047-2054. eCollection 2018. ICF&WB ; Rat.
[IF=2.741] Tara Bocking. et al. Research article expression of surfactant protein-A and D, and CD9 in lungs of 1 and 30 day old foals. Bmc Vet Res. 2021 Dec;17(1):1-9 WB,IHC ; Foal.
[IF=0.267] Tai-Wen Raoet al. Effect of oxygen supplement during targeted temperature management on acute lung injury in the early stage of traumatic hemorrhagic shock. European Journal of Inflammation
Volume 18: 1–7 WB ; rabbit.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞表面分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 25 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SFTPA2/SFTPA1: 23-120/248 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009] Function: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Subunit: Oligomeric complex of 6 set of homotrimers. Subcellular Location: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. DISEASE: Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Similarity: Belongs to the SFTPA family. Contains 1 C-type lectin domain. Contains 1 collagen-like domain. SWISS: Q8IWL2 Gene ID: 653509 Database links: Entrez Gene: 653509 Human Omim: 178630 Human SwissProt: Q8IWL2 Human Unigene: 535295 Human 肺泡表面活性物質(zhì)A（SP-A）屬糖結(jié)合蛋白家族,參與肺泡表面活性膜的形成和代謝,除在Ⅱ型細(xì)胞中強(qiáng)烈表達(dá)外，在細(xì)支氣管、支氣管上皮內(nèi)也有灶性表達(dá)。 |
| 產(chǎn)品圖片 |
Formalin-fixed and paraffin embedded mouse lung tissue labeled Anti-SP-A Polyclonal Antibody, Unconjugated (bs-0770R) at 1:2000, followed by conjugation to the secondary antibody and DAB staining
Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-SP-A Polyclonal Antibody, Unconjugated(bs-0770R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-SP-A Polyclonal Antibody, Unconjugated(bs-0770R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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