| 產(chǎn)品編號(hào) | bs-1542R |
| 英文名稱 | CCR6 Rabbit pAb |
| 中文名稱 | 細(xì)胞表面趨化因子受體6（CD196）抗體 |
| 別 名 | CKR6; C-C chemokine receptor type 6; BN 1; BN1; C C chemokine receptor type 6; C C CKR 6; CC chemokine receptor type 6; CC CKR 6; CC R6; CCCKR6; CCR 6; CD 196; CD196; CD196 antigen; Chemokine(C C motif) receptor 6; Chemokine(C C) receptor 6; Chemokine(CC |
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Specific References (3) | bs-1542R has been referenced in 3 publications.
[IF=7.242] Anne-Lise Paris. et al. Sublingual protein delivery by a mucoadhesive patch made of natural polymers. Acta Biomater. 2021 Apr;: IHC ; Mouse.
[IF=4.757] Shan Huang. et al. Aberrant Activation of the STING-TBK1 Pathway in γδ T Cells Regulates Immune Responses in Oral Lichen Planus. BIOMEDICINES. 2023 Mar;11(3):955 WB ; Human.
[IF=3.457] Zheng X et al. Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. (2018) Biomedicine & Pharmacotherapy.108,1141–1151. IHC ; Human.
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| 研究領(lǐng)域 | 腫瘤 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR6 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] Function: Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P51684 Gene ID: 1235 Database links: Entrez Gene: 1235 Human Entrez Gene: 12458 Mouse Omim: 601835 Human SwissProt: P51684 Human SwissProt: O54689 Mouse Unigene: 46468 Human Unigene: 8007 Mouse CCR6/CD196也是是屬于G蛋白偶聯(lián)受體一家族成員，參與調(diào)節(jié)白細(xì)胞的遷移和活性作用，是細(xì)胞膜蛋白。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human HepG2 cell lysates
Lane 2: Human MCF-7 cell lysates
Primary: Anti-CCR6 (bs-1542R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kDa
Observed band size: 41 kDa
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