强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
狠狠人妻久久久久久综合蜜桃,日韩精品在线播放
首頁 > 產品中心 > 一抗 > 產品信息
LRP1 Rabbit pAb (bs-2677R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2677R
英文名稱 LRP1 Rabbit pAb
中文名稱 低密度脂蛋白受體相關蛋白1抗體
別    名 A2MR; alpha 2 macroglobulin receptor; alpha 2MR; APOER; Apolipoprotein E receptor; APR; CD 91; CD91; CD91 antigen; Low density lipoprotein receptor related protein 1; Low density lipoprotein related protein 1; LRP 1; LRP 515; LRP 85; LRP; LRP ICD; LRP1 protein; LRP515; LRP1_HUMAN.  
Specific References  (1)     |     bs-2677R has been referenced in 1 publications.
[IF=4.044] Tetsuya Shimokawa. et al. Prosaposin in the rat oviductal epithelial cells. 2020 Nov 26  IF ;  Rat.  
研究領域 腫瘤  心血管  細胞生物  免疫學  神經生物學  信號轉導  轉錄調節(jié)因子  合成與降解  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1μg /test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 85/515 kDa
檢測分子量
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LRP1: 4451-4545/4545 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Function:
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Subcellular Location:
Cell membrane. Membrane, coated pit and Cytoplasm. Nucleus. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.

Tissue Specificity:
Most abundant in liver, brain and lung.

Post-translational modifications:
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
The N-terminus is blocked.
Phosphorylated on serine and threonine residues.
Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.

Similarity:
Belongs to the LDLR family.
Contains 22 EGF-like domains.
Contains 31 LDL-receptor class A domains.
Contains 34 LDL-receptor class B repeats.

SWISS:
Q07954

Gene ID:
4035

Database links:

Entrez Gene: 4035 Human

Entrez Gene: 16971 Mouse

Entrez Gene: 299858 Rat

SwissProt: Q07954 Human

SwissProt: Q91ZX7 Mouse



產品圖片
Tissue/cell: Mouse brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-LRP1 Polyclonal Antibody, Unconjugated(bs-2677R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: Mouse lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-LRP1 Polyclonal Antibody, Unconjugated(bs-2677R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Blank control(blue):U937 (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-LRP1 antibody(bs-2677R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
版權所有 2004-2026 nmgps.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
91人妻一区二区三区 | 99人妻少妇无码αⅤ二区下载 | 国产寡妇婬乱A毛片视频m | 欧美黑人猛插性爱视频 | 囯产精品久久久久久久久久乐趣播 | 国精产品999永久麻豆一区二区 | 2019年免费中文大全 | 四川少妇BBw搡BBBB槡BBBB 鲁鲁狠狠狠7777一区二区 | 国产毛片精品一区二区色欲黄A片 | 红桃成人网站在线观看 | 免费无码婬片AAAA片直播色戒 | 亚洲国产精品狼友在线观看 | 亚洲熟女乱色综合亚洲AV | 男女在线搞黄色国产 | 嫩草一区二区国产乱码99人妻 | 国产又爽又大又黄A片色戒一 | 91麻豆情侣丝袜在线 | 国产在线精品国自产拍 | 6080午夜精品无码 | 麻豆美女裸体AAAA片 | 精品国产18久久久久久二百 | 少妇搡BBBB搡BBB搡澳门 | 欧美特一级aaaaa | 国产日韩成人精品一区二区 | 91人妻人人爽人人添夜夜爽直软件播 | 中文字幕日韩精品无码内射 | 国产传媒在线播放亚洲专区 | 亚洲精品无码成人片久久-涡桑剁 | 波多野结衣一区二区香蕉加勒比 | 久久婷含羞草无码A区 | 韩国青草自慰喷水无码 | 绿色成人免费AV网站 | 新av在线天堂网 | 中字人妻伦欲中文字幕下载 | 国产精品久久久久久中文字 | 精品亚洲自慰无码喷奶水 | 国产免费婬乱男女婬视频 | 欧美人与禽乱婬A片 | 爱咲れいら无码一区二区 | 免费一级一级人妻a片 | 日韩欧美高清在线观看 |