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phospho-Nrf2 (Ser40) Rabbit pAb (bs-2013R)

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產(chǎn)品編號(hào)	bs-2013R
英文名稱	phospho-Nrf2 (Ser40) Rabbit pAb
中文名稱	磷酸化核因子2相關(guān)因子2(Ser40)抗體
別名	NF2L2_HUMAN; Nuclear factor erythroid 2-related factor 2; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; Nrf 2; Nuclear factor, erythroid derived 2, like 2; NFE2L2; NRF2; NFE2 like bZIP transcription factor 2; HEBP1; IMDDHH;
	Specific References (48) \| bs-2013R has been referenced in 48 publications. [IF=9.274] Wiebke Sachs. et al. Distinct Modes of Balancing Glomerular Cell Proteostasis in Mucolipidosis Type II and III Prevent Proteinuria. J Am Soc Nephrol. 2020 Aug;31(8):1796-1814 WB,IF ; Mouse. PubMed:32641396 [IF=8.071] Ming Qi. et al. Ellagic acid ameliorates paraquat-induced liver injury associated with improved gut microbial profile. Environ Pollut. 2022 Jan;293:118572 WB ; Pig. PubMed:34838710 [IF=7.446] Jianbing Wu. et al. Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO2–) Donors as Potential Anticerebral Ischemia Agents. J Med Chem. 2021;XXXX(XXX):XXX-XXX IHC ; Rat. PubMed:34292749 [IF=7.376] Ziling Wang. et al. Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling. Free Radical Bio Med. 2021 Aug;: WB ; Mouse. PubMed:34364981 [IF=7.376] Ziling Wang. et al. Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling. Free Radical Bio Med. 2021 Aug;: WB ; Mouse. PubMed:34364981 [IF=7.19] Mo, Chunfen, et al. "The Crosstalk between Nrf2 and AMPK Pathways Is Important for the Anti-inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice."?Antioxidants & redox signaling?ja (2013). PubMed:23875776 [IF=7.129] Jie Luo. et al. Copper nanoparticles lead to reproductive dysfunction by affecting key enzymes of ovarian hormone synthesis and metabolism in female rats. ECOTOX ENVIRON SAFE. 2023 Apr;254:114704 WB ; Rat. PubMed:36898311 [IF=6.922] Yunxiao Zhong. et al. Nrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis. J Inflamm Res. 2022 Feb;15:669-685 WB ; Rat. PubMed:35140498 [IF=6.819] Kim, Da-Eun. et al. Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21cip1 signaling in acute kidney injury. CELL BIOL TOXICOL. 2022 Jul;:1-21 WB ; Rat. PubMed:35842499 [IF=6.656] Ye Yang. et al. Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway. PHYTOMEDICINE. 2023 Feb;110:154625 WB ; Rat. PubMed:36586206 [IF=6.388] Rui Ji. et al. Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation. PHYTOTHER RES. 2023 Feb;: WB ; Mouse,Human. PubMed:36786429 [IF=6.205] Michelle L. Kerns. et al. Pathogenic and therapeutic role for NRF2 signaling in ultraviolet light–induced skin pigmentation. Jci Insight. 2020 Oct 15; 5(20): e139342 IF,IHC ; Human, Mouse. PubMed:33001866 [IF=5.74] Santofimia-Casta?o, Patricia, et al. "Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca 2+ influx activation in mouse pancreatic acinar cells." Free Radical Biology and Medicine (2015). Rat. PubMed:26163001 [IF=5.27] Lee, Bao-Hong, et al. "Dimerumic acid attenuates receptor for advanced glycation endproduct (RAGE) signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promoted methylglyoxal metabolism into D-lactate acid" Free Radical Biology and Medicine WB ; Human, Mouse. PubMed:23434766 [IF=5.27] Lee, Bao-Hong, et al. "Ankaflavin: A natural novel PPAR?? agonist up-regulated Nrf2 to attenuate methylglyoxal (MG)-induced diabetes< i> in vivo."Free Radical Biology and Medicine (2012).y WB ; Rat. PubMed:23022408 [IF=5.201] Marina K et al. Mesenchymal Stem Cells Early Response to Low-Dose Ionizing RadiationFront Cell Dev Biol.2020 Dec 14;8:584497. FCM ; Human. PubMed:33381502 [IF=5.187] Ana L. Vivinetto. et al. Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo. Bba-Mol Basis Dis. 2022 Apr;1868:166324 IF ; Rat. PubMed:34954343 [IF=5.03] Yen, Ting-Lin, et al. "Andrographolide stimulates p38 MAPK-Nrf2-HO-1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats." Translational Research (2016). WB ; Mouse. PubMed:26746802 [IF=4.925] Xueling Zhang. et al. Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway. INVEST OPHTH VIS SCI. 2022 Nov;63(12):25-25 WB ; Human. PubMed:36383351 [IF=4.716] Gong H et al. Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation. Front Immunol. 2020 Mar 10;11:414. WB ; Mouse. PubMed:32210977 [IF=4.556] Jong Ik Jeonet al. Bacteroides fragilis Enterotoxin Induces Sulfiredoxin-1 Expression in Intestinal Epithelial Cell Lines Through a Mitogen-Activated Protein Kinases- and Nrf2-Dependent Pathway, Leading to the Suppression of Apoptosis. Int J Mol Sci . 2020 Jul 29;21(15):5383. WB ; Human. PubMed:32751114 [IF=4.48] Cárdeno, Ana, et al. "Squalene targets pro-and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages." Journal of Functional Foods 14 (2015): 779-790. WB ; Human. PubMed:doi:10.1016/j.jff.2015.03.009 [IF=4.412] Ning Zhou. et al. Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H2O2. MOLECULES. 2022 Jan;27(11):3542 WB ; Duck. PubMed:35684483 [IF=4.315] Hao Huang. et al. Maintaining blood retinal barrier homeostasis to attenuate retinal ischemia-reperfusion injury by targeting the KEAP1/NRF2/ARE pathway with lycopene. Cell Signal. 2021 Dec;88:110153 WB,IF ; Human. PubMed:10.1016/j.cellsig.2021.110153 [IF=4.29] Ghosh, Anindya, et al. "Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice." Endocrinology 158.4 (2017): 903-919. WB ; Mouse. PubMed:28324005 [IF=4.119] Cheng-You Lu. et al. Calycosin alleviates H2O2-induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO-1 signaling pathway. 2022 Jan 06 WB ; Rat. PubMed:34990515 [IF=4.109] Jhong-Kuei Chen. et al. Artemisia argyi extract ameliorates IL-17A-induced inflammatory response by regulation of NF-κB and Nrf2 expression in HIG-82 synoviocytes. ENVIRON TOXICOL. 2022 Aug;: WB ; Rabbit. PubMed:35959841 [IF=3.961] Ghosh et al. Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice. (2017) Endocrinology. 158:903-919 WB ; Mouse. PubMed:28324005 [IF=3.85] Kim, Mi-Hwi, et al. "EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage." Toxicology and Applied Pharmacology (2016). WB ; Rat. PubMed:27939242 [IF=3.73] Ko, Su Hyuk, et al. "Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinases-and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis." Infection and Immunity (2016): IAI-00191. IF(ICC) ; Mouse. PubMed:27324483
產(chǎn)品類型	磷酸化抗體
研究領(lǐng)域	免疫學(xué) 染色質(zhì)和核信號(hào) 細(xì)胞凋亡轉(zhuǎn)錄調(diào)節(jié)因子激酶和磷酸酶
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human,Mouse (predicted: Rat,Cow,Chicken,Dog)
產(chǎn)品應(yīng)用	WB=1:500-2000,ICC/IF=1:100 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	68 kDa
檢測(cè)分子量
細(xì)胞定位	細(xì)胞核細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40: DF(p-S)QR
亞型	IgG
純化方法	affinity purified by Protein A
緩沖液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產(chǎn)品介紹	Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar (CNC-bZIP) subfamily of basic /leucine zipper (bZIP) transcription factors. Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Subunit: Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1. Subcellular Location: Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. Tissue Specificity: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. Post-translational modifications: Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. Similarity: Belongs to the bZIP family. CNC subfamily. Contains 1 bZIP domain. SWISS: Q16236 Gene ID: 4780 Database links: Entrez Gene: 4780 Human Omim: 600492 Human SwissProt: Q16236 Human
產(chǎn)品圖片	Sample: Lane 1: Hela (Human) Cell Lysate at 30 ug Lane 2: HepG2 (Human) Cell Lysate at 30 ug Lane 3: MCF-7 (Human) Cell Lysate at 30 ug Lane 4: Jurkat (Human) Cell Lysate at 30 ug Lane 5: B16 (Human) Cell Lysate at 30 ug Lane 6: A549 (Human) Cell Lysate at 30 ug Primary: Anti-phospho-Nrf2 (Ser40) (bs-2013R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68 kD Observed band size: 135 kD HepG2 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (phospho-Nrf2 (Ser40)) polyclonal Antibody, Unconjugated (bs-2013R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

	免疫組化常用試劑
	免疫印跡常用試劑
	各種標(biāo)記二抗

	1、抗體溶解方法
	2、抗體修復(fù)方式
	3、常用試劑的配制
	4、免疫組化操作步驟
	5、免疫組化問題解答
	6、Western Blotting 操作步驟
	7、Western Blotting 問題解答
	8、關(guān)于肽鏈的設(shè)計(jì)
	9、多肽的溶解與保存
	10、酶標(biāo)抗體效價(jià)測(cè)定程序

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