| 產(chǎn)品編號(hào) | bs-6185R |
| 英文名稱 | RSPO1 Rabbit pAb |
| 中文名稱 | 分泌性蛋白R(shí)SPO1抗體 |
| 別 名 | R-spondin-1; R spondin1; CR spondin 1; RISTIN3; FLJ40906; hRspo1; R spondin homolog(Xenopus laevis); R spondin homolog; Roof plate specific spondin; Roof plate-specific spondin-1; RP11-566C13.1; RSPO; RSPO1_HUMAN. |
| 研究領(lǐng)域 | 發(fā)育生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 27 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RSPO1: 131-230/263 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Subunit: Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Subcellular Location: Secreted. Tissue Specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. DISEASE: Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:610644]. This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Similarity: Belongs to the R-spondin family. Contains 2 FU (furin-like) repeats. Contains 1 TSP type-1 domain. SWISS: Q2MKA7 Gene ID: 284654 Database links: Entrez Gene: 284654 Human Entrez Gene: 192199 Mouse Omim: 609595 Human SwissProt: Q2MKA7 Human SwissProt: Q9Z132 Mouse Unigene: 135015 Human Unigene: 42202 Mouse R-spondin（Rspo）是近年來(lái)新發(fā)現(xiàn)的蛋白家族,包括4個(gè)成員（Rspo1～4）。Rspo蛋白家族所有成員均為分泌性蛋白,均有兩個(gè)富含半胱氨酸的furin-like結(jié)構(gòu)域、1個(gè)TSP1結(jié)構(gòu)域和富含堿性氨基酸的C端區(qū)域。Rspos通過激活并協(xié)同Wnt/β-catenin信號(hào)通路參與對(duì)細(xì)胞增殖和分化的調(diào)控,影響骨骼、肌肉、血管等組織的發(fā)育以及肢體和性腺的形成,并在多種疾病的發(fā)生過程中起重要作用。 |
