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SARM1 Rabbit pAb (bs-9001R)  
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50ul/1180.00元
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200ul/2800.00元
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產(chǎn)品編號 bs-9001R
英文名稱 SARM1 Rabbit pAb
中文名稱 SARM蛋白抗體
別    名 FLJ36296; KIAA0524; MyD88-5; SAM and ARM-containing protein; SAM domain-containing protein 2; SAMD2; SARM 1; SARM1; SARM1_HUMAN; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and HEAT/Armadillo motifs-containing protein; sterile alpha and TIR motif containing 1; Sterile alpha and TIR motif-containing protein 1; Sterile alpha and TIR motifs-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog.  
Specific References  (1)     |     bs-9001R has been referenced in 1 publications.
[IF=2.992] Cuiqin Zhang. et al. Atg7 Knockout Alleviated the Axonal Injury of Neuro-2a Cells Induced by Tri-Ortho-Cresyl Phosphate. 2021 Mar 01  WB ;  Mouse.  
研究領(lǐng)域 細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 80 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SARM1: 321-420/724 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.

Function:
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.

Subunit:
Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

Similarity:
Contains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain.

SWISS:
Q6SZW1

Gene ID:
23098

Database links:

Entrez Gene: 23098 Human

Entrez Gene: 237868 Mouse

Omim: 607732 Human

SwissProt: Q6SZW1 Human

SwissProt: Q6PDS3 Mouse

Unigene: 446689 Human

Unigene: 743510 Human

Unigene: 210332 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Human liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SARM1) Polyclonal Antibody, Unconjugated (bs-9001R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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