| 產(chǎn)品編號 | bs-11105R |
| 英文名稱 | Ninjurin 1 Rabbit pAb |
| 中文名稱 | 神經(jīng)損傷誘導(dǎo)蛋白1抗體 |
| 別 名 | Nerve injury induced protein 1; Nerve injury-induced protein 1; NIN1; NINJ1; NINJ1_HUMAN; NINJURIN; Ninjurin-1. |
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Specific References (3) | bs-11105R has been referenced in 3 publications.
[IF=9.587] Shi Yunhong. et al. N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1. J NEUROINFLAMM. 2023 Dec;20(1):1-18 WB ; Mouse.
[IF=6.086] Minoshima?A et al. Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2358-2370. IHC ; Mouse.
[IF=3.68] Matsuki, Motoki, et al. "Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes." Circulation Journal 0 (2015). IHC-F ; Mouse.
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| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 16 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Ninjurin 1: 1-80/152 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Ninjurin family proteins are muli-pass membrane proteins induced by nerve injury in Schwann cells and dorsal root ganglion neurons. Nunjurin proteins act as homophilic cell adhesion molecules that promote axonal growth. Ninjurin proteins also play a role in the formation and function of other tissues. Ninjurin-1 is widely expressed in adult and embryonic tissues, particularly those with epithelial origin. Ninjurin-2 is also widely expressed, with highest levels in adult bone marrow and peripheral blood lymphocytes and embryo liver, thymus and heart. The genes that encode the Ninjurin proteins map to a region known to cause several genetic disorders, including hereditary sensory neuropathy type I and type II (HSN1 and HSN2). However, no link between mutations in the genes encoding Ninjurins and the diseases have been found. Function: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin. Similarity: Belongs to the ninjurin family. SWISS: Q92982 Gene ID: 4814 Database links: Entrez Gene: 4814 Human Omim: 602062 Human SwissProt: Q92982 Human Unigene: 494457 Human Unigene: 11245 Rat |
