| 產(chǎn)品編號 | bs-11270R |
| 英文名稱 | FKBP4 Rabbit pAb |
| 中文名稱 | 熱休克蛋白56抗體 |
| 別 名 | FKBP4_HUMAN; Peptidyl-prolyl cis-trans isomerase FKBP4; EC:5.2.1.8; FKBP52; PPIase FKBP4; 51 kDa FK506-binding protein(FKBP51); 52 kDa FK506-binding protein(52 kDa FKBP; FKBP-52); 59 kDa immunophilin(p59); FK506-binding protein 4(FKBP-4); Peptidyl-prolyl |
| 研究領(lǐng)域 | 信號轉(zhuǎn)導(dǎo) 細(xì)胞骨架 細(xì)胞外基質(zhì) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 52 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSP56: 1-100/459 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. Subunit: Homodimer. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with HSF1 in the HSP90 complex. Associates with tubulin (By similarity). Interacts with MAPT/TAU (By similarity). Interacts with NR3C1 and dynein (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction. Subcellular Location: Cytoplasm; cytosol. Nucleus. Cytoplasm; cytoskeleton. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Similarity: Contains 2 PPIase FKBP-type domains. Contains 3 TPR repeats. SWISS: Q02790 Gene ID: 2288 Database links: Entrez Gene: 2288 Human Entrez Gene: 14228 Mouse SwissProt: Q02790 Human SwissProt: P30416 Mouse 有研究表明；FKBP52蛋白可能防止Tau蛋白的過度磷酸化，F(xiàn)KBP52可控制致病性Tau蛋白的異常產(chǎn)生。當(dāng)AD患者的神經(jīng)細(xì)胞FKBP52水平降低時，致病性Tau蛋白將不會沉積，將不能促進(jìn)腦細(xì)胞的變性，F(xiàn)KBP52蛋白是迄今為止發(fā)現(xiàn)的唯一一個有抗Tau蛋白特性的蛋白。FKBP52蛋白能降低阿爾茨海默氏癥患者大腦中致病性Tau蛋白的產(chǎn)生。 |
