| 產(chǎn)品編號(hào) | bs-10407R |
| 英文名稱 | Thrombopoietin Rabbit pAb |
| 中文名稱 | 血小板生成素/巨核細(xì)胞集落刺激因子抗體 |
| 別 名 | c mpl ligand; C-mpl ligand; Megakaryocyte Colony Stimulating Factor; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Megakaryocyte stimulating factor; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative Leukemia Virus Oncogene Ligand; THPO; Thrombopoietin; Thrombopoietin nirs variant 1; TPO; TPO_HUMAN. |
 |
Specific References (1) | bs-10407R has been referenced in 1 publications.
[IF=12.52] Nakamura-Ishizu, Ayako, et al. "CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow." The Journal of experimental medicine (2015): jem-20150057. IHC-F ; Mouse.
|
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 干細(xì)胞 細(xì)胞周期蛋白 細(xì)胞分化 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 37 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Thrombopoietin: 21-120/353 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012]. Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Subcellular Location: Secreted. DISEASE: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the EPO/TPO family. SWISS: P40225 Gene ID: 7066 Database links: Entrez Gene: 7066 Human Entrez Gene: 21832 Mouse Omim: 600044 Human SwissProt: P40225 Human SwissProt: P40226 Mouse Unigene: 1166 Human Unigene: 3943 Mouse Unigene: 10576 Rat |
| 產(chǎn)品圖片 |
Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti-Thrombopoietin (bs-10407R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 37 kD
Observed band size: 35 kD
|
