| 產(chǎn)品編號 | bs-17076R |
| 英文名稱 | KAT2A/GCN5 Rabbit pAb |
| 中文名稱 | 組蛋白乙?；D(zhuǎn)移酶GCN5抗體 |
| 別 名 | 1110051E14Rik; AW212720; EC 2.3.1.48; GCN 5; GCN5(general control of amino acid synthesis yeast homolog) like 2; GCN5(general control of amino-acid synthesis, yeast, homolog)-like 2; Gcn5; GCN5 general control of amino acid synthesis 5 like 2; GCN5 general control of amino-acid synthesis 5-like 2(yeast); GCN5 like 2; GCN5L2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5 like 2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis yeast homolog like 2; General control of amino acid synthesis, yeast, homolog-like 2; HGCN 5; HGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KAT2 A; KAT2A; KAT2A_HUMAN; Lysine acetyltransferase 2A; MGC102791; PCAF-b; STAF97. |
| 研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 94 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KAT2A/GCN5: 601-700/837 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] Function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Subcellular Location: Nucleus. Tissue Specificity: Expressed in all tissues tested, with most abundant expression in ovary. Similarity: Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain. SWISS: Q92830 Gene ID: 2648 Database links: Entrez Gene: 2648 Human Entrez Gene: 14534 Mouse Omim: 602301 Human SwissProt: Q92830 Human SwissProt: Q9JHD2 Mouse Unigene: 463045 Human Unigene: 218837 Mouse |
