| 產(chǎn)品編號(hào) | bs-10993R |
| 英文名稱 | HRH4 Rabbit pAb |
| 中文名稱 | 組織胺H4受體抗體 |
| 別 名 | GPCR105; GPRv53; H4 antibody H4R; HH4R; Histamine H4 receptor; AXOR35; BG26; G protein coupled receptor 105; HRH4_HUMAN; SP9144. |
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Specific References (2) | bs-10993R has been referenced in 2 publications.
[IF=6.986] Bando, Kanan. et al. Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate. INFLAMM RES. 2022 Oct;:1-15 IHC ; Mouse.
[IF=6.038] Liao, Xiaodan. et al. Fullerene nanoparticles for the treatment of ulcerative colitis. 2021 Nov 02 WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse HRH4: 101-200/391 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q91ZY2 Gene ID: 225192 Database links: Entrez Gene: 59340 Human Entrez Gene: 225192 Mouse Omim: 606792 Human SwissProt: Q9H3N8 Human SwissProt: Q91ZY2 Mouse Unigene: 287388 Human Unigene: 207073 Mouse Unigene: 162272 Rat |
| 產(chǎn)品圖片 |
Protein: brain(mouse) lysate at 40ug;
Primary: rabbit Anti-HRH4 (bs-10993R) at 1:300;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000;
Predicted band size: 44 kD
Observed band size: 44 kD
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