| 產(chǎn)品編號(hào) | bs-0390R |
| 英文名稱 | beta 2 Microglobulin Rabbit pAb |
| 中文名稱 | β2-微球蛋白抗體 |
| 別 名 | B2M; beta-2-MG; beta 2 microglobulin precursor; beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; beta-2 microglobin; beta 2 microglobulin precursor; beta chain of mhc class 1 proteins; beta chain of MHC class I molecules; beta-2-microglobulin for β2 Microglobulin; β2-Microglobulin; β-2-Microglobulin; |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 13/27 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human Beta-2-Microglobulin protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]. Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Subunit: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Subcellular Location: Secreted. Note=Detected in serum and urine. Post-translational modifications: Glycation of Ile-21 is observed in long-term hemodialysis patients. DISEASE: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Similarity: Belongs to the beta-2-microglobulin family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SWISS: P61769 Gene ID: 567 Database links: Entrez Gene: 567 Human Entrez Gene: 12010 Mouse Omim: 109700 Human SwissProt: P61769 Human SwissProt: P01887 Mouse Unigene: 534255 Human Unigene: 702947 Human Unigene: 163 Mouse Unigene: 1868 Rat 小鼠抗人β2微球蛋白在中樞神經(jīng)系統(tǒng)感染、腫瘤及全身性自身免疫性疾病患者腦脊液中，會(huì)出現(xiàn)β2MG蛋白不同程度的增高。 |
| 產(chǎn)品圖片 |
Sample:
Raji(Human) Cell Lysate at 30 ug
Primary: Anti-beta 2 Microglobulin (bs-0390R) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 13/27 kD
Observed band size: 48 kD
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