| 產(chǎn)品編號 | bsk11010 |
| 英文名稱 | Human IL-10 ELISA Kit |
| 中文名稱 | 白細(xì)胞介素10酶聯(lián)免疫試劑盒 |
| 別 名 | Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. |
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Specific References (6) | bsk11010 has been referenced in 6 publications.
[IF=17.521] Lizhen He. et al. Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy. Advanced Science. 2023 Jan;:2202519 ELISA ; Human.
[IF=12.479] Qi Chen. et al. Ruthenium complexes boost NK cell immunotherapy via sensitizing triple-negative breast cancer and shaping immuno-microenvironment. Biomaterials. 2022 Jan;:121371 ELISA ; Human.
[IF=10.273] Lai H et al. Selenium-containing ruthenium complex synergizes with natural killer cells to enhance immunotherapy against prostate cancer via activating TRAIL/FasL signaling. Biomaterials. 2019 Jul 24;219:119377. ELISA ; Human.
[IF=8.702] Zhang Mengqi. et al. Exosomal Mir-3613-3p derived from oxygen–glucose deprivation-treated brain microvascular endothelial cell promotes microglial M1 polarization. CELL MOL BIOL LETT. 2023 Dec;28(1):1-14 ELISA ; Human.
[IF=8.079] Qiu, Zhenhua. et al. Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial–myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels. STEM CELL RES THER. 2022 Dec;13(1):1-15 WB ; Human.
[IF=5.999] Cheng Chen. et al. Effects of substrate topography on the regulation of human fibroblasts and capsule formation via modulating macrophage polarization. COLLOID SURFACE B. 2023 Feb;222:113086 ELISA ; Human.
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| 種 屬 | Human |
| 線性范圍 | 7.8 - 500 pg/mL |
| 應(yīng)用范圍 | S/P/CC |
| 檢測限 | 4 pg/mL |
| 適用樣品基質(zhì) | cell culture supernates, serum, and plasma. |
| 保存條件 | Store at 4°C for 12 months. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. 白細(xì)胞介素-10(IL-10)是主要由Th2細(xì)胞所產(chǎn)生的一種細(xì)胞因子，活化的B細(xì)胞、單核巨噬細(xì)胞和枯否氏細(xì)胞（Kupffer's cell）等也可產(chǎn)生IL-10。它是以抑制Th細(xì)胞克隆細(xì)胞因子合成為特點(diǎn)的多效免疫調(diào)節(jié)因子。 白介素-10是維護(hù)細(xì)胞因子網(wǎng)絡(luò)平衡的重要負(fù)調(diào)節(jié)因子。其作用機(jī)制可能是降低抗原遞呈細(xì)胞MHCⅡ類抗原表達(dá)，或誘導(dǎo)抗原遞呈細(xì)胞產(chǎn)生另一種細(xì)胞因子，改變細(xì)胞內(nèi)信號傳遞途徑，從而選擇性抑制某些細(xì)胞因子mRNA轉(zhuǎn)錄，并與Th2細(xì)胞產(chǎn)生的IL-4、IL-5有協(xié)同作用。 |
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