| 產品編號 | V5225 |
| 英文名稱 | phospho-Tau (Thr217) Mouse mAb |
| 中文名稱 | 磷酸化微管相關蛋白單克隆抗體 |
| 別 名 | Tau (phospho T217); p-Tau (phospho T217); Tau(Phospho-Thr217); MAPT(phospho T217); p-Tau(Thr217); MAPT; Microtuble-associted protein Tau; AI413597; AW045860; DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Prote |
| 克 隆 號 | 2F5 |
| 理論分子量 | 46/79 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 0.01M PBS(pH7.4). |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品介紹 |
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. SWISS: P10636 Gene ID: 4137 tau蛋白是腦內神經元細胞支架蛋白之一.其正常功能是促進微管蛋白組成微管,并維持已形成微管的穩(wěn)定性.參與維持細胞形態(tài)、信息傳遞、細胞分裂等重要生物學過程,是軸突生長發(fā)育和神經元極性形成的不可缺少因素. 近年來發(fā)現(xiàn)tau蛋白與一些中樞神經系統(tǒng)變性疾病密切相關,尤其是神經Tau具有啟動微管系統(tǒng)的裝配以及穩(wěn)定微管系統(tǒng)的作用，該蛋白的錯誤折疊與老年性癡呆等神經退行性疾病密切相關. |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
