| 產(chǎn)品編號(hào) | D62117 |
| 英文名稱(chēng) | Avapritinib |
| 中文名稱(chēng) | |
| 別 名 | BLU-285 |
| CAS | 1703793-34-3 |
| 理論分子量 | 498.5579832 kDa |
| 檢測(cè)分子量 | |
| 保存條件 | -20℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 |
