| 產(chǎn)品編號 | bsm-63092R |
| 英文名稱 | P53 Recombinant Rabbit mAb |
| 中文名稱 | 細(xì)胞腫瘤抗原P53蛋白重組兔單抗 |
| 別 名 | P53_HUMAN; Cellular tumor antigen p53; TP53; Antigen NY-CO-13;Phosphoprotein p53; Tumor suppressor p53; tumor protein p53; BCC7; LFS1; BMFS5; TRP53; P 53; P-53; wt-p53; Widespread p53; Wtp53; Wt p53; |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 3D10 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=1:20-50,ICC/IF=1:50-200,IP=1:20-50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44 kDa |
| 檢測分子量 | 55 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P53 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. SWISS: P04637 Gene ID: 7157 wtp53廣泛的研究發(fā)現(xiàn)P53腫瘤抑制基因?qū)?0%以上的人類癌癥具有抑制突變的功能。P53蛋白水平在正常細(xì)胞中表達(dá)低，在DNA突變時或各種各樣細(xì)胞遇難信號時反應(yīng)增加。該基因突變或缺失是導(dǎo)致許多腫瘤發(fā)生的原因。 野生型P53(wt-p53)可誘導(dǎo)細(xì)胞凋亡，并通過細(xì)胞凋亡抑制腫瘤生長，而P53的突變或缺失則可抑制野生型P53的功能，使得缺陷細(xì)胞得以存活下來，從而導(dǎo)致腫瘤發(fā)生。 P53同時也是細(xì)胞凋亡的調(diào)控因子。此抗體可用于P53腫瘤抑制基因功能的研究。 |
