產(chǎn)品編號(hào) | bs-6753R-FITC |
英文名稱 | Rabbit Anti-WWP1/FITC Conjugated antibody |
中文名稱 | FITC標(biāo)記的WW結(jié)構(gòu)域E3泛素連接酶1抗體 |
別 名 | AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 腫瘤細(xì)胞生物標(biāo)志物 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Rat, (predicted: Human, Mouse, Dog, Cow, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 105kDa |
細(xì)胞定位 | 細(xì)胞膜 |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human WWP1 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers. Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Subunit: Binds KLF2 AND HIVEP3. Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with RNF11. Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase. Interacts with TGIF. Subcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Tissue Specificity: Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. Post-translational modifications: Auto-ubiquitinated and ubiquitinated by RNF11. Similarity: Contains 1 C2 domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 4 WW domains. Database links: Entrez Gene: 11059 Human Entrez Gene: 107568 Mouse Omim: 602307 Human SwissProt: Q9H0M0 Human SwissProt: Q8BZZ3 Mouse Unigene: 655189 Human Unigene: 144867 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 亚洲AV无码免在线观看玉蒲团 | 97人妻精品一区二区三区动漫 | 无码人妻精品一区二区三区蜜臀 | 久久99精品久久久久 | 精品國產亂子倫一區二區 | 肉欲丰满少妇1~5集全 | 少妇的肉体AAAAA免费视频 | 中文字幕无码高清 | 成年人视频免费在线观看 | 2022天天干在线视频 | 鲁大师影院在线观看网站入口 | 3d动漫H精品一区二区三区 | 免费很黄很爽很污入口 | 亚洲天堂无码视频 | 麻豆精品秘 国产传媒AV | 国产成人av一区二区 | 色欲av永久无码精品无码蜜桃 | 精品无码人妻口爆日本欧美 | 岳乱一区二区三区免费看 | va婷婷在线免费观看 | 国产精品无码人妻无码色情多人 | 久久久久成人精品无码 | 日韩理论视频一本二本 | 拍真实国产伦偷精品 | 又大又粗又硬又爽又黄毛片视频 | 蜜桃AV一区二区三区 | 国产熟妇肥臀多毛BBW | 少妇搡BBBB搡BBB搡野外 | 国产成人亚洲精品无码h在线 | 日本精品中文字幕人妻 | 91丨九色丨国产 在线 | 国产电影中文字幕无码 | 人人干天天搞夜夜爽 | 日本无码熟妇五十路视频 | 欧美成人做爰高潮片免费看借种 | 国产裸体视频BBBBB | 国产乱婬AAAA片视频 | 稀缺小u女呦品呦视频 | 国产福利姬喷白浆流水 | 国产寡妇婬乱A毛片视频 |