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Rabbit Anti-Vesicular Acetylcholine Transporter/Cy7 Conjugated antibody (bs-1833R-Cy7)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1833R-Cy7
英文名稱 Rabbit Anti-Vesicular Acetylcholine Transporter/Cy7 Conjugated antibody
中文名稱 Cy7標記的囊泡乙酰膽堿通道抗體
別    名 Vesicular Acetylcholine Transporter; MGC12716; rVAT; SLC18A3; Solute carrier family 18 (vesicular acetylcholine) member 3; Solute carrier family 18 (vesicular monoamine) member 3; Solute carrier family 18 member 3; VACht; VAChT; VACHT_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  免疫學  神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAT
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Vesicular Acetylcholine Transporter (VAChT), (~70kD protein), belongs to the family of vesicular monoamine transporters(VMATs), which include VMAT1 and VMAT2 and the C.elegans putative ACh transporter unc-17. Members of this family function to concentrate neurotransmitters into synaptic vesicles through exchange of protons for neurotransmitters. VAChT is a functional transporter for the neurotransmitter acetylcholine(ACh). ACh is synthesized in the cytoplasm by choline acetyl transferase (ChAT) and transported by VAChT into synaptic vesicles where it is stored until released. After release from presynaptic nerve terminals ACh is hydrolyzed by extracellular ACh-esterases(AChE) to choline and acetate.
VAChT mRNA is expressed in all known major cholinergic neurons in the central and peripheral nervous system. VAChT is abundantly expressed in the CNS and is mainly localized in small synaptic vesicles in cholinergic nerve terminals. VAChT provides a specific marker for cholinergic neurons for the study of cholinergic transmission in experimental models, in Alzheimer’s disease and other nervous system disorders.

Function:
Involved in acetylcholine transport into synaptic vesicles.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Peripheral and central cholinergic nervous systems.

Similarity:
Belongs to the major facilitator superfamily.
Vesicular transporter family.

Database links:

Entrez Gene: 6572 Human

Entrez Gene: 20508 Mouse

Entrez Gene: 60422 Rat

Omim: 600336 Human

SwissProt: Q16572 Human

SwissProt: O35304 Mouse

SwissProt: Q62666 Rat

Unigene: 654374 Human

Unigene: 190503 Mouse

Unigene: 9987 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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