產(chǎn)品編號(hào) | bs-2641R-PE-Cy5.5 |
英文名稱 | Rabbit Anti-Integrin alpha 6/PE-Cy5.5 Conjugated antibody |
中文名稱 | PE-Cy5.5標(biāo)記的整合素α6抗體 |
別 名 | Integrin alpha 6; Alpha 6; B cell associated molecule CD40; CD 49f; CD49f; ITGA6; CD40 antigen; CD40 type II isoform; CD49f; CD49f antigen; Integrin alpha chain; ITGA 6; ITGA6; ITGA6B; Nerve growth factor receptor related B lymphocyte activation molecule; p50; Tumor necrosis factor receptor superfamily member 5 precurso; VLA 6 alpha subunit; VLA 6; Integrin α6. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞粘附分子 淋巴細(xì)胞 b-淋巴細(xì)胞 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, (predicted: Mouse, Rat, Chicken, Cow, ) |
產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 21/124kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Integrin alpha 6 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis. Function: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). [PTM] Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. Post-translational modifications: Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. DISEASE: Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Database links: Entrez Gene: 3655 Human Entrez Gene: 16403 Mouse Omim: 147556 Human SwissProt: P23229 Human SwissProt: Q61739 Mouse Unigene: 133397 Human Unigene: 225096 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产护士囗交吞精视频 | 日本一级特黄大真人片 | 60厘米黑人又粗又大又硬 | 国产亚洲无码视频精品 | 国产第一A片成人网站777 | 精品秘 无码一区二区久久 国产精久久 网站漫画 | 国产精品国产三级国芦专播精品人 | 四川丰满少妇被弄到高潮 | 国产精品 国产18 | 日本親子亂子倫XXXX50路 | 激情综合五月丁香狠狠爱 | 海角社区一级A片免费看 | 91丨色丨国产熟女 蘑 | 午夜无码片在线观看影院 | 欧美韩日综合一区 | 欧美A级成人婬片免费看 | 亚洲性爱在线观看 | 色婷婷无码人妻一三五区 | 在线无码精品秘入口 | 国产一级久久久久毛片精品 | 丰满人妻A片二区 | 成人午夜伦理福利电影 | 美女美裸体视频一区二区 | 一级毛片中文字幕免费的 | 红桃视频成人影视www | 免费一级特黄特色大片 | 噜噜噜狠狠夜夜躁精品仙踪林 | 久久久久久久久久久久久久动漫 | 波多野结衣无码电影 | 国产熟女毛多水大高潮 | 国产在线拍揄自揄拍无码网站新闻 | 国产日本无码视频韩国网站写真 | 黄色高清无码在线观看 | 国产91无码精品秘 入口、 | 亚洲欧美国产日韩综合 | 精品国产乱码久久久久久蜜柚 | 国产网站在线免费观看 | 美日韩丰满少妇在线观看 | 91精品人妻人人做人碰人人爽 | 在线免费观看黄色视频网址 |