| 產(chǎn)品編號(hào) | bs-2423R-AP |
| 英文名稱 | Rabbit Anti-DLK1/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的穿膜蛋白DLK1抗體 |
| 別 名 | Adipocyte differentiation inhibitor protein; Brevideltin; Delta like 1 homolog; Delta like homolog; Delta like protein; Delta1; DLK 1; DLK; DLK-1; Dlk1; DLK1_HUMAN; FA 1; FA1; Fetal antigen 1; pG2; Preadipocyte factor 1; Pref 1; Pref; Pref1; Pref-1; Protein delta homolog 1; Secredeltin; ZOG; Delta1; PREF1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 細(xì)胞表面分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Pig, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DLK1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]. Function: May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 6 EGF-like domains. Database links: Entrez Gene: 8788 Human Entrez Gene: 13386 Mouse Omim: 176290 Human SwissProt: P80370 Human SwissProt: Q09163 Mouse Unigene: 533717 Human Unigene: 157069 Mouse Unigene: 14547 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 穿膜蛋白DLK1又稱肝癌相關(guān)基因，是表皮生長(zhǎng)因子(EGF)家族的成員之一,其結(jié)構(gòu)特征為蛋白的細(xì)胞外區(qū)域擁有在結(jié)構(gòu)及氨基酸序列上與表皮生長(zhǎng)因子高度同源的重復(fù)結(jié)構(gòu).DLK1可以抑制脂肪前體細(xì)胞向脂肪細(xì)胞分化,在正常神經(jīng)內(nèi)分泌細(xì)胞及其腫瘤細(xì)胞中表達(dá), DLK1在神經(jīng)內(nèi)分泌軸中起著調(diào)控細(xì)胞生長(zhǎng)分化的作用,同時(shí)DLK1在胚胎肝、造血干細(xì)胞及早期肌肉組織中均有表達(dá)。 |
