產(chǎn)品編號(hào) | bs-11098R-BF488 |
英文名稱 | Rabbit Anti-NLGN2/BF488 Conjugated antibody |
中文名稱 | BF488標(biāo)記的神經(jīng)連接蛋白2抗體 |
別 名 | NL2; Neuroligin 2; Ortholog of human and rat neuroligin 2 NLGN2. KIAA1366; MGC67386; RP23-422L16.24; NLGN2_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說(shuō) 明 書 | 100ul |
研究領(lǐng)域 | 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞膜蛋白 |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 90kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human NLGN1 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses. Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with INADL. Interacts with GPHN. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina. Tissue Specificity: Expressed in the blood vessel walls. Detected in colon, brian and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. Similarity: Belongs to the type-B carboxylesterase/lipase family. Database links: Entrez Gene: 57555 Human Entrez Gene: 216856 Mouse Omim: 606479 Human SwissProt: Q8NFZ4 Human SwissProt: Q69ZK9 Mouse Unigene: 26229 Human Unigene: 55111 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 欧美成人一区三区无码乱码A片 | 日韩精品无码人妻第一页 | 亚洲成人中文字幕 | 影音先锋在线观看资源网 | 欧美日韩国产一二三区 | 亚洲AV秘 无码一区二区三竹菊 | 骚货人妻被操巨乳 | 欧美激情婬乱A片无码放荡娇妻 | 熟女人妻 人妻の视频 | 久久精品yywww麻豆md一区 | 四虎最新成人永久网站 | 波多野结衣亚洲色 | 国产一区二三区免费A片惊变 | 免费国偷拍精品视频 | 成人A片潘金莲在线观看九色 | 一级特黄妇女高潮视的特点 | 成人A片网站发布地址 | 国产乱码一区二区三区在线观看 | 亚洲AV无码乱码A片无码沈樵 | 国模无码一区二区三区 | 国产黄色红桃视频二区 | 夜夜躁狠狠躁日日躁 | 欧美一级婬片免费视频黄 | 91视频免费在线观看 | 17C嫩嫩草色视频蜜桃 | 骚虎影视作成人在线观看 | 午夜国产A久久片亚洲最大 欧美性猛交AAAA片黑人 | 小12萝自慰喷白浆网站 | 91 黑料 精品 国产 | 91国產乱高潮白浆 | 国产女团裸体无遮挡A片 | 国产凹凸熟女一区二区三区 | 欧–美–性–交–黄–片 | 四房色播丁香五月 | 欧美交换乱婬A片免费 | 西西4444WWW无码视频 | 亚洲中文无码在线观看 | 妺妺窝人体色444444大粗 | 77777少妇AAAAA片毛片 | 九九国产精品在线观看 |