產(chǎn)品編號(hào) | bs-11958R-BF594 |
英文名稱 | Rabbit Anti-OTX1 + OTX2/BF594 Conjugated antibody |
中文名稱 | BF594標(biāo)記的轉(zhuǎn)錄因子OTX1+OTX2抗體 |
別 名 | FLJ38361; Homeobox protein OTX 1; Homeobox protein OTX1; Homeobox protein OTX2; MCOPS 5; MCOPS5; MGC15736; MGC45000; Orthodenticle 1; Orthodenticle 2; Orthodenticle homeobox 1; Orthodenticle homeobox 2; Orthodenticle homolog 1; Orthodenticle homolog 2 (Drosophila); Orthodenticle homolog 2; Orthodenticle1; Orthodenticle2; Otx 1; Otx 2; otx1; OTX1_HUMAN; otx2; OTX2_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 干細(xì)胞 表觀遺傳學(xué) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 37/32kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human OTX1 + OTX2 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively. Function: Function: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Subcellular Location: Nucleus Tissue Specificity: Expressed in brain. DISEASE: Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. Similarity: Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 5013 Human Entrez Gene: 5015 Human Entrez Gene: 18423 Mouse Entrez Gene: 30501 Zebrafish SwissProt: P32242 Human SwissProt: P32243 Human SwissProt: P80205 Mouse SwissProt: P80206 Mouse SwissProt: Q91981 Zebrafish Unigene: 288655 Human Unigene: 445340 Human Unigene: 129663 Mouse Unigene: 134516 Mouse Unigene: 334 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产亚洲精品久久久久2029 | 国产91嫩草乱婬A片2蜜臀 | 苍井さくら无码AV无破坏流出 | 中文字幕无码永久无线无码蜜桃视频 | 做爱视频免费在线观看 | 蜜桃狠狠狠狠狠狠狠 | 久久人妻嫩草无码AV专区动漫 | 国产寡妇亲子伦一区二区三区四区 | 四州少妇BBw搡BBBB小说 | 香港AV无码三级免费 | 百度一下久久久久久久久久免费 | 91亚洲精品国偷拍 | 男女啪啪视频喷水爆操桃香奈木 | 欧美媚黑国产一区二区 | 一级黄色片三级黄色 | 91一区二区三区 | 亚洲中文字幕A V奸 蜜桃av网站在线浏览 | 毛多水多丰满女人A片 | 波多野结衣一区二区三区在线观看 | 《艳妇荡乳》在线观看 | 蜜桃av秘 无码一区二区三欧 | 国产高清免费在线观看 | 可以在线观看的av | 国产女教师一爽A片 | 做爰高潮A片〈毛片〉 | 红桃视频一区二区三区四区 | 美女很黄很黄的免费网站 | 国产日韩精品无码去免费专区国产 | 中文字幕永久字幕永久在线 | 99人妻碰碰碰久久久久禁片 | 国产三级黄色性感毛片大全 | 中文简体视频人妻 | 囯产精品久久久久久久久 | 夜夜春亚洲嫩草直播蜜桃 | 四川少妇BBBw搡BBBB搡BBBB | 国产91久久婷婷一区二区 | 欧美午夜操逼福利大片 | 国产在线观看国产精品产拍 | 国产精品高潮呻吟久久 | 本田岬久久精品一区二区 |