產(chǎn)品編號(hào) | bs-3779R-BF647 |
英文名稱 | Rabbit Anti-Histone H2A/H2A.1/BF647 Conjugated antibody |
中文名稱 | BF647標(biāo)記的組蛋白H2A抗體 |
別 名 | H2a 615; H2A; H2A GL101; H2A histone family member A; H2A.1; H2A.2; H2A/a; H2A/m; H2A/O; H2A/q; H2AFA; H2AFE; H2AFL; H2AFM; H2AFO; H2AFQ; HIST1H2AE; HIST1H2AJ antibody HIST2H2AA; HIST2H2AA3; HIST2H2AB; HIST2H2AC; Histone 1 H2ae; Histone 2 H2aa3; Histone 2 H2ab; Histone 2 H2ac; Histone H2A type 1 B; Histone H2A type 1 C; Histone H2A type 1 E; Histone H2A type 1 J; MGC74460. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué) 染色質(zhì)和核信號(hào) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 14kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Histone H2A |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]. Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Subcellular Location: Nucleus. Chromosome. Post-translational modifications: The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable). Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events. Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Similarity: Belongs to the histone H2A family. Database links: Entrez Gene: 3012 Human Entrez Gene: 317772 Human Entrez Gene: 8335 Human Entrez Gene: 8337 Human Entrez Gene: 8338 Human Entrez Gene: 319166 Mouse Omim: 142720 Human Omim: 602786 Human Omim: 602797 Human SwissProt: P04908 Human SwissProt: P28001 Human SwissProt: P35065 Human SwissProt: Q93077 Human SwissProt: Q99878 Human SwissProt: P10812 Mouse SwissProt: P22752 Mouse Unigene: 121017 Human Unigene: 248174 Human Unigene: 408067 Human Unigene: 417332 Human Unigene: 434195 Human Unigene: 261665 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 人爽人爽人爽人爽人人 | X9X9X9搡BBBB搡BBB 囯产精品久久久久久久久在饯观看 | 国产又粗又长又爽视频 | 寡妇高潮A片免费看 | 国产精品 同 | 亚洲AV无码秘 蜜桃希岛爱理 | 成人做爰xXX视频看片 | 黄色视频网站在线下载 | 欧美精品久久久久 | 成人毛片18女人毛片 | 毛多浓密老熟女洗澡自拍 | 免费人妻AV无码专区 | 成人无码区免费A片视频野外 | 桃花影院午夜伦A片韩国 | 国产家庭乱日本中文一区 | 人人妻人人澡人人爽人 | 秘书丝袜人妻中文字幕 | 国产农村妇女AAAAA视频 | 无码人妻精品一区二区蜜桃视频 | 日韩一区二区三区四区 | 成年人黄色蜜桃网站 | 亚洲欧美一二三区91蜜桃臀久久一区 | 99成人乱码一区二区三区在线 | 国产伦子伦对白在线播放观看 | 亚洲喷白浆一区二区 | 精品免费国产一区二区三区四区 | 精产国品一二三产品区红桃视频 | 国产黃色A片三区三区三小说 | 特级西西4444日本少妇 | 国偷自产Av一区二区三区换脸 | 午夜理理伦一级A片 | 乱色熟女人妻字幕一区 | 午夜男人多天堂A片免费 | 丰满少妇无套内谢A片免费台湾 | 人妻午夜AAAAA视频 | 亚洲AV无码乱码精品裸果 | 蜜桃AV鲁一鲁一鲁一鲁樱花影院 | 蜜桃无码人妻丰满熟妇区五十路i | 国产喷白浆一区二区三区动漫 | 韩国婬乱高潮AAAA片 |