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Rabbit Anti-Gax/PE-Cy5.5 Conjugated antibody (bs-1250R-PE-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1250R-PE-Cy5.5
英文名稱 Rabbit Anti-Gax/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的生長(zhǎng)終止特異性同源盒基因抗體
別    名 growth arrest-specific homeobox; Homeobox protein MOX-2; Mesenchyme homeobox 2; mesenchyme homeobox 2-like; Growth arrest-specific homeobox; GAX; growth arrest homeobox transcription factor GAX; mesenchyme homeobox 2; MEOX2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gax
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimers disease.

Function:
Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

Subunit:
Interacts with RNF10.

Subcellular Location:
Nucleus. Nucleus speckle.

Similarity:
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 4223 Human

Entrez Gene: 17286 Mouse

Entrez Gene: 29279 Rat

Omim: 600535 Human

SwissProt: P50222 Human

SwissProt: P32443 Mouse

SwissProt: P39020 Rat

Unigene: 170355 Human

Unigene: 341398 Mouse

Unigene: 34890 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gax主要在血管平滑肌細(xì)胞和內(nèi)皮細(xì)胞中表達(dá)的同源異形盒基因,但Gax基因過表達(dá)可以抑制血管平滑肌細(xì)胞和內(nèi)皮細(xì)胞的增殖,Gax也是脊椎動(dòng)物肢體發(fā)育的重要調(diào)節(jié)因子,目前除用于心血管方面的研究,也用于腫瘤血管方面的探索。
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