| 產(chǎn)品編號 | bs-6797R-BF488 |
| 英文名稱 | Rabbit Anti-CRR9/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的順氯氨鉑耐藥相關(guān)蛋白9抗體 |
| 別 名 | Cisplatin resistance related protein 9; Cisplatin resistance related protein CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1 like protein; Cleft lip and palate transmembrane protein 1-like protein; CLP1L_HUMAN; CLPTM1 like; CLPTM1 like protein; CLPTM1-like protein; CLPTM1L; CRR9; CRR9p. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Horse, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLPTM1L/CRR9 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate and the hard palate. Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximately one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. CLPTM1L (cleft lip and palate transmembrane protein 1-like protein), also known as CRR9p (cisplatin resistance-related protein 9) is a 538 amino acid multi-pass membrane protein that belongs to the CLPTM1 family and, when overexpressed, enhances cisplatin-mediated apoptosis. CLPTM1L exists as two alternatively spliced isoforms encoded by a gene that maps to human chromosome 5p15.33. Function: Enhances cisplatin-mediated apoptosis, when overexpressed. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Similarity: Belongs to the CLPTM1 family Database links: Entrez Gene: 81037 Human Omim: 612585 Human SwissProt: Q96KA5 Human Unigene: 444673 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 順氯氨鉑屬于細(xì)胞周期非特異性藥物，具有細(xì)胞毒性，可抑制癌細(xì)胞的DNA復(fù)制過程，并損傷其細(xì)胞膜上結(jié)構(gòu)，有較強(qiáng)的廣譜抗癌作用。臨床用于卵巢癌、前列腺癌、睪丸癌、肺癌、鼻咽癌、食道癌、惡性淋巴瘤、乳腺癌、頭頸部鱗癌、甲狀腺癌及成骨肉瘤等多種實(shí)體腫瘤均能顯示療效。 |
