| 產(chǎn)品編號(hào) | bs-6846R-AP |
| 英文名稱(chēng) | Rabbit Anti-Nucleostemin/AP Conjugated antibody |
| 中文名稱(chēng) | 堿性磷酸酶（AP）標(biāo)記的核干細(xì)胞因子鳥(niǎo)嘌呤核苷酸結(jié)合蛋白3抗體 |
| 別 名 | E2 induced gene 3 protein; E2IG3; Estradiol induced nucleotide binding protein; GNL3; Guanine nucleotide binding protein like 3 (nucleolar); Guanine nucleotide binding protein like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP binding protein 3; Nucleostemin; Putative nucleotide binding protein estradiol induced; C77032; GNL3_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 干細(xì)胞 細(xì)胞類(lèi)型標(biāo)志物 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nucleostemin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Nucleostemin is a protein found in the nucleoli of embryonic stem cells, adult CNS stem cells, primitive cells in the bone marrow and cancer cells. It is not in the differentiated cells of most adult tissues. It has been suggested to play a role in controlling the cell cycle progression in stem cells and cancer cells. Function: May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. Subunit: Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity). Subcellular Location: Nucleus. Nucleus. nucleolus. Shuttles between the nucleus and nucleolus. Tissue Specificity: Increased levels in lung tissue in cancer patients. Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. Contains 1 G (guanine nucleotide-binding) domain. Database links: Entrez Gene: 26354 Human Entrez Gene: 30877 Mouse Omim: 608011 Human SwissProt: Q9BVP2 Human SwissProt: Q8CI11 Mouse Unigene: 313544 Human Unigene: 88512 Mouse Unigene: 4110 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
