產(chǎn)品編號 | bs-1117R-APC |
英文名稱 | Rabbit Anti-GPR49/APC Conjugated antibody |
中文名稱 | APC標記的G蛋白偶聯(lián)受體49抗體 |
別 名 | G protein coupled receptor 49; G-protein coupled receptor 49; G-protein coupled receptor 67; GPCR GPR49; G protein coupled receptor 67; FEX; g protein-coupled receptor fex; G-protein coupled receptor HG38; GPR 49; GPR 67; GPR49; GPR67; Leucine rich repeat containing G protein coupled receptor 5; LGR5; HG 38; HG38; LGR5; LGR5_HUMAN; MGC117008; Leucine-rich repeat-containing G-protein coupled receptor 5; LGR 5; Orphan G protein coupled receptor HG38. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導 干細胞 細胞凋亡 G蛋白偶聯(lián)受體 G蛋白信號 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, (predicted: Rat, Chicken, Dog, Cow, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 98kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from mouse GPR49 C-terminus |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] Function: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. Subunit: Identified in a complex composed of RNF43, LGR5 and RSPO1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. Similarity: Belongs to the G-protein coupled receptor 1 family. Contains 16 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. Database links: Entrez Gene: 8549 Human Entrez Gene: 14160 Mouse Omim: 606667 Human SwissProt: O75473 Human SwissProt: Q9Z1P4 Mouse Unigene: 658889 Human Unigene: 42103 Mouse Unigene: 214063 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Lgr5基因(Wnt細胞信號系統(tǒng))是一種G蛋白偶聯(lián)受體,已經(jīng)被確定為幾種成年組織和癌癥中干細胞的一個獨特標記。Lgr5最初是在結(jié)腸癌細胞中發(fā)現(xiàn)的,有報道稱:在惡化前的小鼠腺瘤中也有發(fā)現(xiàn),這說明Lgr5很可能也是其他組織成體干細胞和癌癥干細胞的標志物。 |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關(guān)于肽鏈的設(shè)計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |
| 丰满多毛大隂户XXXHD | 国产成人精品秘久久久 | 草1024榴社区成人影院 | 蜜桃AV不卡无码三区 | 99久久精品一区二区成人 | 在线免费电影中文字幕av | 亚洲激情视频在线观看 | 无码人妻精品一区二区三区老鸭窝 | 精品人伦一区二区三区suv | 娇妻呻吟一区二区三区 | 美女美乳摸摸日日夜夜 | 国产精品揄拍100视频 | 国产一级特黄a高潮片 | 老熟妇高潮一区二区高清视频 | 一区二区三区四区国产 | 亚洲无码免费高清视频 | 日本黑人乱偷人妻中文 | 白嫩小泬BBB免费观看 | 91在线无码精品秘国产 | 精品人妻一区二区三区影院 | AAA级黄色视频网站 欧美一级婬片A片无码 | 91九色视频在线播放 | 艳妇乳肉豪妇荡乳AV无码一区 | 熟女 人妻蜜臀av一区二区三区 | 蜜桃中文字日产乱幕4区 | A片试看50分钟做受视频 | 中字无码在线电影资源 | 99久久无码一区人妻A片贼王 | 少妇性BBB搡BBB | 国产一级大黄毛片在线看 | 7777精品久久久久久 | 1000部啪啪毛片免费看 | 波多野结衣大喷高潮视频 | 后入内射欧美99二区视频 | 四川BBB搡BBB搡多人刮 | 成人3D动漫一区二区三区91 | 中文字幕人妻av | 国产69精品久久久久久久久久久久 | 一级在线免费观看视频 | 国产精品免费福利姬 |