强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品国产91乱码一区二区三区,无码人妻一区二区三区在线,91精品久久久久久久99蜜桃
Rabbit Anti-Lpin1 protein/BF350 Conjugated antibody (bs-0760R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0760R-BF350
英文名稱 Rabbit Anti-Lpin1 protein/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的Lpin1 抗體
別    名 EC=3.1.3.4; KIAA0188; LPIN1; PAP1; Phosphatidate phosphatase LPIN1; HDLCQ11; Lipase; LIPD; LIPOPROTEIN LIPASE; Lipoprotein lipase 1; LPL; MGC137861; MGC93586; LPIN1_MOUSE.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  信號轉(zhuǎn)導(dǎo)  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Lpin 1 protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism.
LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Function:
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.

Subunit:
Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C.

Subcellular Location:
soform 1: Mitochondrion outer membrane. Cytoplasm. Nucleus membrane. Note=Recruited at the mitochondrion outer membrane following phosphatidic acid formation mediated by PLD6. In neuronals cells, isoform 1 is exclusively cytoplasmic. In 3T3-L1 pre-adipocytes, it primarily located in the cytoplasm.
Isoform 2: Nucleus. Cytoplasm. Endoplasmic reticulum membrane. Note=Nuclear localization requires both CNEP1R1 and CTDNEP1. In neuronals cells, localized in both the cytoplasm and the nucleus. In 3T3-L1 pre-adipocytes, it is predominantly nuclear.

Tissue Specificity:
Specifically expressed in skeletal muscle. Also expressed prominently in adipose tissue, and testis. Lower expression also detected in kidney, lung, brain and liver. Isoform 1 is the predominant isoform in the liver. Isoform 2 is the major form in the brain.

Post-translational modifications:
Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex.
Sumoylation is important in brain and is marginal in other tissues. Sumoylation facilitates nuclear localization of isoform 2 in neuronals cells and its transcriptional coactivator activity.

DISEASE:
Note=Defects in Lpin1 are the cause of the fatty liver dystrophy phenotype (fld). Fld mutant mices are characterized by neonatal fatty liver and hypertriglyceridemia that resolve at weaning, and neuropathy affecting peripheral nerve in adulthood. Adipose tissue deficiency, glucose intolerance and increased susceptibility to atherosclerosis are associated with this mutation too. Two independent mutant alleles are characterized in this phenotype, fld and fld2j.

Similarity:
Belongs to the lipin family.

Database links:

Entrez Gene: 23175 Human

Entrez Gene: 14245 Mouse

Entrez Gene: 313977 Rat

Omim: 605518 Human

SwissProt: Q14693 Human

SwissProt: Q91ZP3 Mouse

Unigene: 467740 Human

Unigene: 153625 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Lpin1 protein主要用于脂酯代謝異常、胰島素抵抗及肥胖方面的研究。
該蛋白在肝,肺,腎,胎盤,脾臟,胸腺,淋巴結(jié),前列腺,睪丸,小腸和大腸等組織中都有程度不同的表達。
版權(quán)所有 2004-2026 nmgps.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
熟女人妻国产精品30p | 国产麻豆一区二区三区 | 国产精品被狂躁到高潮 | 国产成人精品大尺度在线观看 | 成人性做爰全过程免费 | 国产91无码精品秘 入口 | 寡妇熟妇高潮片AAA 国产黄片在线免费观看 | 免费观看国产又大又长又粗又黄的A√片 | 狠狠色综合AV夜色撩人 | 国产91清纯白嫩初高中 | 国产AV高潮虐朝喷 | 日本超骚少妇熟妇视频 | 美女又爽 又黄 视频 | Qwww乱岳妇熟com| 最新无码人妻在线不卡 | 日韩网站在线观看 | 欧美韩国日本国产精品三级片视频 | 日本三级午夜理伦三级三 | 无码人妻精品一区二区三区蜜臀 | 久久99嫩草熟妇人妻蜜臀 | 2021人人操人人爱 | 久久久久亚洲AV无码专区男同 | 黄色WwW网站在线观看 | 秘书丝袜人妻中文字幕 | 欧美mv日韩mv国产 | 国产做受免费无码A片国语 亚洲第一精品人人澡人人爽 | 鲁鲁视频国产在线播放 | 色先锋影音A∨资源网 | 少妇嫩模自慰喷潮A片 | 亚洲人成色777777精品音频 | 日产精品无码一级毛片 | 中文字幕的电影免费网站 | 艹欧美美女免费网站 | 国产精品人人妻人人爽30p | 国产精品国产三级国产播12软件 | 小14萝裸体毛片免费看 | 免费国产传媒av在线观看 | 欧美成人dvd在线视频 | 强伦轩一级A片在线观看 | 毛片网站无码网红国产 | AV无码免费观看 |