| 產(chǎn)品編號 | bs-7888R-AP |
| 英文名稱 | Rabbit Anti-Cyclin L/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的周期素L抗體 |
| 別 名 | Ania 6a; BM 001; CCNL 1; CCNL1; CCNL1_HUMAN; Cyclin L ania 6a; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞周期蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, Chimpanzee, mpanzee) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cyclin L/CCNL1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. Tissue specificity;Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). Function: Transcriptional regulator which participates inregulating the pre-mRNA splicing process. Seems to be involved inthe regulation of RNA polymerase II (pol II). Functions inassociation with cyclin-dependent kinases (CDKs) and has a role inthe second step of splicing. May be a candidate proto-oncogene inhead and neck squamous cell carcinomas (HNSCC). Inhibited by theCDK-specific inhibitor p21. Subunit: Interacts with POLR2A via its hyperphosphorylatedC-terminal domain (CTD) (By similarity). Interacts with CDK11A,CDK11B, CDK12, CDK13 and SFRS2. Subcellular Location: Nucleus speckle (By similarity). Note=Morespecifically found in nuclear intrachromatin granules clusters(IGC), also called nuclear speckles, which are storage compartmentsfor nuclear proteins involved in mRNA processing (By similarity). Tissue Specificity: Ubiquitous with higher level in thymus.Overexpression in primary tumors of head and neck squamous cellcarcinomas (HNSCC). Similarity: Belongs to the cyclin family. Cyclin L subfamily. Database links: UniProtKB/Swiss-Prot: Q9UK58.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
