產(chǎn)品編號 | bs-9125R-BF350 |
英文名稱 | Rabbit Anti-COPS2/BF350 Conjugated antibody |
中文名稱 | BF350標(biāo)記的甲狀腺受體相互作用蛋白15抗體 |
別 名 | ALIEN; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; COPS 2; Cops2; CSN2; CSN2_HUMAN; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; Thyroid Hormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 51kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human COPS2/TRIP15 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Subunit: Interacts with NIF3L1 (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Interacts with CUL1 and CUL2. Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Phosphorylated by CK2 and PKD kinases. Similarity: Belongs to the CSN2 family. Contains 1 PCI domain. Database links: UniProtKB/Swiss-Prot: P61201.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 寡妇高潮一级毛片随便看 | 搡老女人51妇女老熟女 | 人人妻人人澡人人爽人人精品图片 | 东北免费黄色电影网站 | 四川寡妇BBB搡BBB爽爽爽 | 成人精品毛片内射视频 | 无码流出●苍井そら | 黄片视频在线观看免费 | 日韩精品无码中文视频 | 91人妻人人人人爽 | 黄色在线网站蜜桃 | av一区二区三区四区 | 久久久亚洲AV无码午 | 91少妇偷拍洗澡在线播放 | 人与禽一级婬片A片69式按摩 | 成人 高潮片免费视频 | 西西4444WWW无码精品 | 欧美一级搡BBBB搡BBBB | 久久国产精品99久久人人澡 | 影音先锋每日资源 | 蜜桃av秘 乱码一区二区三区 | 国产又粗又大又黄视频在线观看 | 国产精品成人国产乱一区 | 国产91国语对白在线 | 免费在线观看黄色视频 | 嗯嗯嗯啊啊好爽十八禁网站 | 欧美一级特黄AA大片 | 东北少妇BBBB搡BBB搡 | 精国产品一区二区三区A片 91麻豆产精品久久久久久 | 特级西西www大胆无码 | 无码粉嫩虎白国产在线观看 | 成人AV一区二区三区 | 国产亚洲精品成人a v久久网站 | 亚洲精品久久久久毛片A级绿茶 | 欧美性猛交XXXXX水多 | 国产偷窥熟妇高潮呻吟 | 免费无码婬片AAAA片小说下载 | 久久人妻少妇嫩草av | 国产熟女丝袜喷水在线 | 懂色av浪潮av色欲av熟妇 |