產(chǎn)品編號(hào) | bs-5505R-Cy7 |
英文名稱 | Rabbit Anti-phospho-MAPKAPK5(Ser93)/Cy7 Conjugated antibody |
中文名稱 | Cy7標(biāo)記的磷酸化p38調(diào)節(jié)/激活蛋白激酶抗體 |
別 名 | MAPKAPK5(phospho S93); MAP kinase-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase. |
規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
說 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, ) |
產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 52kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human MAPKAPK5 around the phosphorylation site of Ser93 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The serine/threonine kinase PRAK is activated in response to cellular stress and proinflammatory cytokines, through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38 alpha, and MAPK11/p38 beta. PRAK has been reported to have a putative tumor suppressor function by mediating senescence upon activation by p38 in response to oncogenic ras. It is thought that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras induced senescence and tumor suppression. Function: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. Subunit: Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct. Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Interacts with SQSTM1. Subcellular Location: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export. Tissue Specificity: Expressed ubiquitously. Post-translational modifications: Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 久久人妻无码毛片A片麻豆 亚洲乱码精品久久久久.. | 近親相姦五十路のお | 海角社区乱子伦视频播放 | 苍井空波多野结衣AA片 | 91人妻系列绿帽精品蜜臀 | 年轻少妇A片免费观看 | 成人小黄书免费网站入口3D | 欧美日韩亚洲一区二区三区 | 西西8888www无码 | 99久久婷婷国产一区二区三区 | 波多野结衣一区二区 | 国产一区二区三区四区在线观看 | 欧美一级特黄又粗又硬 | 成年人黄色视频免费观看 | 裸体美女动漫网站在线观看 | 青青青的成人免费视 | 亚洲高清免费视频 | 人妻无码一区二区三区四区在线 | 性猛交一级A片少妇视频无码 | 亚洲美女高潮久久久久 | 一级老太卖婬免费视频 | 91丝袜精品久久久久久无码人妻 | 一牛影视文化传媒有限公司官网网站 | 成人av在线一区二区 | 又粗又长又硬xxxx | 中文无码精品一区二区三区 | 婬片野外A片AAA毛片啊 | 再深点灬舒服灬受不了的播放地址 | 欧美精品无码一区二区成人片 | 92成人做爰A片免费看 | 泼多野结衣乳巨码无在线 | 国产熟女鲁鲁视频草莓 | 国产精品免费观看 | 国产又粗又猛又黄又爽无遮挡 | 国内自拍性爱视频在线 | 精品一区二区三区蜜桃视频 | 91蜜桃传媒精品久久久一区二区 | 免费无码婬片AA片按摩 | 波多野佶衣中文字幕久久 | 日本丰满脂肪人人爱视频在线观看50路 |