| 產(chǎn)品編號 | bs-4201R-APC |
| 英文名稱 | Rabbit Anti-FIH1/HIF1AN/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的缺氧誘導(dǎo)因子1α抑制蛋白/HIF1AN抗體 |
| 別 名 | Hypoxia inducible factor asparagine hydroxylase; Factor inhibiting HIF1; FIH 1; FIH-1; FIH1; Hypoxia inducible factor 1 alpha inhibitor; Hypoxia inducible factor 1 alpha subunit inhibitor; Peptide aspartate beta dioxygenase; HIF1AN; DKFZp762F1811; FIH1; HIF1AN; FLJ20615; FLJ22027; HIF1N_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FIH1/HIF1AN |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: HIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor protein to mediate repression of HIF1 transcriptional activity. Function: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation. Subunit: Homodimer; homodimerization is essential for catalyticactivity. Interacts with VHL and HIF1A. Part of a complex with VHL,HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA.Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4.Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A.Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4(By similarity). Interacts with UBE3A. Subcellular Location: Nucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages. Similarity: Contains 1 JmjC domain. Database links: Clone ID: BC007719 Human Entrez Gene: 55662 Human IMAGE Id: 4138066 Human Omim: 606615 Human SwissProt: Q5W147 Human SwissProt: Q9NWT6 Human Unigene: 500788 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
