| 產(chǎn)品編號(hào) | bs-5743R-BF488 |
| 英文名稱 | Rabbit Anti-CDKN3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的細(xì)胞周期蛋白依賴性激酶抑制蛋白3抗體 |
| 別 名 | Cdk associated protein phosphatase; CDI1; CDK2 associated dual specificity phosphatase; CIP2; Cyclin dependent kinase inhibitor 3; Cyclin dependent kinase interactor 1; Cyclin dependent kinase-interacting protein 2; KAP1; Kinase associated phosphatase. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞周期蛋白 激酶和磷酸酶 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDKN3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: CDKN3 is a second dual specificity phosphatase that interacts with cyclin dependent kinases.The ability of CDKN3 to bind multiple cyclin-dependent kinases suggests that it may be a critical control element in cell cycle regulation, presumably by regulating the phosphorylation state of a Cdk or Cdk-associated protein. Function: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Subunit: Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity. Subcellular Location: Cytoplasm, perinuclear region. DISEASE: Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550]. Similarity: Belongs to the protein-tyrosine phosphatase family. Database links: UniProtKB/Swiss-Prot: Q16667.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
