產(chǎn)品編號 | bs-11917R-Bio |
英文名稱 | Rabbit Anti-HRG1/Biotin Conjugated antibody |
中文名稱 | 生物素標(biāo)記的神經(jīng)調(diào)節(jié)蛋白1β2抗體 |
別 名 | Neuregulin 1 beta 2; Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; GGF2; Glial growth factor; Heregulin; HGL; HRG; HRG1; HRGA; NDF; Neu differentiation factor; Neuregulin1; NRG 1; NRG1 beta; Pro-neuregulin-1, membrane-bound isoform; Sensory and motor neuron-derived factor; SMDF; NRG1_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Rat, (predicted: Human, Mouse, Cow, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 24/68kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human HRG1/Neuregulin 1 beta 2 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014] Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Subunit: The cytoplasmic domain interacts with the LIM domain region of LIMK1. Interacts with ERBB3 and ERBB4. Subcellular Location: Cell Membrane, Nuclear and Secreted Tissue Specificity: Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. Post-translational modifications: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage DISEASE: Note=A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines. Similarity: Belongs to the neuregulin family. Contains 1 EGF-like domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Database links: Entrez Gene: 3084 Human Entrez Gene: 211323 Mouse Omim: 142445 Human SwissProt: Q02297 Human Unigene: 453951 Human Unigene: 668810 Human Unigene: 153432 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 91丨欧美熟妇在线 | 综合区亚一洲线观看免费 | 中文字幕丰满人妻无码区隔壁人爱 | 一级按摩A片在线观看 | 黄色录像一二级片人妻少妇 | 精品国产免费一区二区三区香蕉 | 国产又粗又硬又黄的视频 | 亚洲AV无码专区一级婬片毛片 | ..少妇泬出白浆狠狠躁日本动漫 | 国产精品久久久久毛片大屁完整版 | 国产初高中小泬视频 | AV成人一区二区三区 | 无码中文字幕视频在线观看 | 可以直接观看的黄色视频网址 | 久久99热这里只频精品 | 成人无码AV一区二区 | 在线观看亚洲黄色视频网站 | 亚洲色七久久桃花精品影院 | 国精品无码一区二区 | 四lll少妇BBBB槡BBBB | 免费看黃色AAAA片 | 浪潮av蜜臀色欲av无码 | 少妇高潮精品一区二区三区 | 夜精品无码A片一区二区蜜桃 | 久久久久久久久福利视频 | 搡bbbb 搡bbb冒白浆 | 国产又大又粗又黄 | 一级毛片黄久久久免费看A片 | 国产综合永久精品日韩91蜜 | 国产美女裸露无遮挡双奶 | 91人人妻人人爱人人澡人人爽 | 狂暴强伦轩一区二区三区四区 | 国产精品成人AAAAA网站 | 国产黃色A片三級三級三級四川 | 手机在线观看免费国产黄色国语电影 | 韩国888电影午夜不卡网 | 张柏芝二三级在线观看 | 一级在线免费观看视频 | 亚洲成人精品久久 - 百度 | 精品中文字幕综合 |