| 產(chǎn)品編號(hào) | bs-16502R-AP |
| 英文名稱 | Rabbit Anti-HHV8 GPCR/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的人類皰疹病毒8 G蛋白偶聯(lián)受體抗體 |
| 別 名 | Human Herpesvirus 8 GPCR; VGPCR_HHV8P; Kaposi's sarcoma-associated herpesvirus GPCR; KSHV GPCR. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HHV8 GPCR |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8, HHV8), is a gamma herpesvirus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL8, NAP2, PF4, MGSA/Gro alpha, I309, RANTES, MCP1, and MIP1 beta. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression. IP10, a chemokine, can inhibit constitutively activated KSHV GPCR. Function: Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Subunit: Interacts with protein K7; this interaction promotes vGPCR proteasomal degradation. Subcellular Location: Host cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
