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Rabbit Anti-LEPROTL1/BF647 Conjugated antibody (bs-18234R-BF647)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-18234R-BF647
英文名稱 Rabbit Anti-LEPROTL1/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的瘦素受體重疊轉(zhuǎn)錄基因1抗體
別    名 HSPC112; Leprotl1; Leptin receptor overlapping transcript-like 1; LERL1_HUMAN; my047; Vps55.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  生長(zhǎng)因子和激素  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LEPROTL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Mutation of Ob (Obesity factor), also known as leptin precursor, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. LEPROTL1 (Leptin receptor overlapping transcript-like 1) is a 131 amino acid multi-pass membrane protein that is highly homologous to the leptin receptor gene-related protein, Ob-R. LEPROTL1 is widely expressed and contains a JAK binding site. The LEPROTL1 gene is located on chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes.

Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Subcellular Location:
Membrane.

Tissue Specificity:
Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Similarity:
Belongs to the OB-RGRP/VPS55 family.

Database links:

Entrez Gene: 23484 Human

Entrez Gene: 68192 Mouse

Entrez Gene: 361160 Rat

Omim: 607338 Human

SwissProt: O95214 Human

SwissProt: Q9CQ74 Mouse

Unigene: 146585 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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