產(chǎn)品編號(hào) | bs-18980R-HRP |
英文名稱(chēng) | Rabbit Anti-N ras + c Ha ras/HRP Conjugated antibody |
中文名稱(chēng) | 辣根過(guò)氧化物酶標(biāo)記的HRAS1抗體 |
別 名 | ALPS4; GTPase HRas; GTPase NRas; HRAS1; N ras protein part 4; Neuroblastoma RAS viral (v-ras) oncogene homolog; NRAS; Ras family small GTP binding protein H Ras; RAS1; Transforming protein p21. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白信號(hào) |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, (predicted: Rat, Pig, ) |
產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 21kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human N ras + c Ha ras |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008] Function: RAS - the RAS superfamily comprises around 50 related genes encoding GTP-binding domain (G-proteins) involved in signal transduction. The main genes are HRAS, NRAS and KRAS. Ras proteins are membrane-bound GTPases. The inactive form is GDP-bound. They are activated by ligand-binding receptor tyrosine kinases such as EGFR, PDGFR, colony-stimulating factor and fibroblast growth factor. These kinases transiently convert RAS-GDP to RAS-GTP, the active form of RAS. Single amino acid substitutions can activate RAS making it highly oncogenic. Such mutations generally reduce the GTPase activity of RAS, prolonging it in its active GTP-bound form. The consequence of this is sustained activation of the RAF1-MAPK signalling pathway. RAS mutations are found in 10-15% of tumours. A high incidence of RAS mutations is found in pancreatic cancers. Subcellular Location: Plasma membrane associated. Database links: Entrez Gene: 3265 Human Entrez Gene: 4893 Human Omim: 164790 Human Omim: 190020 Human SwissProt: P01111 Human SwissProt: P01112 Human Unigene: 37003 Human Unigene: 486502 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 在线免费黄色视频 | 亚洲精品网站3D动漫之医院 | 国产扒老师丝袜在线观看 | 69麻豆成人精品国产免费 | 国产成人无码A片免费看 | 一区二区三区四区精品 | 91少妇人妻偷人网站 | 欧美一级特黄AAAAA片大水 | 成人免费观看婬片A片 | 91人妻五码一区二区三区 | 国产一级a毛一级a | 人与嘼一区二区三区 | 亚洲第三区无码17c 黄色三级国产色情无码 | 欧美做受 高潮6 | 在线一区二区三区四区 | 色婷婷国产精品秘 免 | 色黄大色黄女片免费看直播 | 日本无码熟妇五十路视频 | 色情午夜 码一区二区 | 91精品国产综合久久久不卡98口 | 亚洲乱熟乱熟女一区二区 | 高清国产一区二区三区 | 亚洲一区二区在线 | 夜夜躁精品AAAAXXXX | 看黄色一级免费的黄色视频 | 成人午夜A片999影视 | 成人午夜福利在线观看 | 少妇一级婬片免费放 | 国产一区三级在线观看免费 | 亚洲AV无码乱码 | 亲子乱婬一级A片 | 成年人在线观看视频 | 给小姐毛片1级强奸毛片 | 亚洲国产精品久久久 | 国产小视频在线不卡 | 亚洲AV成人无码精品直播在线 | 私密按摩级婬片A片免费播 91麻豆秘秘 密入口蜜柚 | 欧美精品成人在线视频 | 免费在线观看www视频 | 少妇搡BBBB搡BBB搡失恋 |