產(chǎn)品編號(hào) | bs-19761R-APC |
英文名稱(chēng) | Rabbit Anti-RBCK1/HBV associated factor 4/APC Conjugated antibody |
中文名稱(chēng) | APC標(biāo)記的乙型肝炎X病毒相關(guān)蛋白4抗體 |
別 名 | XAP3; XAP4; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; HOIL-1; ZRANB4; C20orf18; UBCE7IP3; Chromosome 20 open reading frame 18; HBV associated factor 4; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; Hepatitis B virus X associated protein 4; Hepatitis B virus X-associated protein 4; HOIL 1L; HOIL-1L; HOIL1; HOIL1L; RanBP type and C3HC4 type zinc finger containing 1; RanBP-type and C3HC4-type zinc finger-containing protein 1; RBCC protein interacting with PKC1; Rbck1; RBCK2; RING finger protein 54; RNF54; UB7I3_HUMAN; UBCE7IP3; Ubiquitin conjugating enzyme 7 interacting protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 3. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)菌及病毒 鋅指蛋白 表觀遺傳學(xué) 泛素 |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Mouse, (predicted: Human, Rat, Dog, Cow, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 56kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human RBCK1/HBV associated factor 4 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008] Function: Acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteoasome. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at 'Lys-285' and 'Lys-309' and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types. Subcellular Location: Forms homodimers in vitro (By similarity). Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) and with UBE2L3. Interacts with PRKCH. Interacts with the HBV pX/HBx protein, which is required to activate transcription of the viral genome. Isoform 1 and isoform 2 interact with IREB2 only in iron-rich conditions. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1. Interacts with IRF3. Post-translational modifications: Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome. Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disease characterized by polyglucosan storage myopathy associated with early-onset progressive muscle weakness and progressive dilated cardiomyopathy, which may necessitate cardiac transplant in severe cases. Some patients present with severe immunodeficiency, invasive bacterial infections and chronic autoinflammation. Similarity: Contains 1 B box-type zinc finger. Contains 1 RanBP2-type zinc finger. Contains 1 RING-type zinc finger. Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 10616 Human Entrez Gene: 24105 Mouse Omim: 610924 Human SwissProt: Q9BYM8 Human SwissProt: Q9WUB0 Mouse Unigene: 247280 Human Unigene: 182145 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 精产国品一区二区不卡 | 性爱插插插动态图120秒免费看 | 国产人妻人伦精品1国产丝袜 | 日日鲁鲁夜夜爽爽爽狠狠 | 少妇一区二区三区四区 | 国产免费人做人爱 | 麻豆免费看片视频MV | 老熟妇-x88AV| 无码人妻一2三区69岛 | 内射后入在线观看一区 | 91熟女乱老熟女成熟50 | 污视频网站在线观看免费 | 无码人妻丰满熟妇区毛片老年人 | 欧美成人午夜无码A片 | 少妇水多A片太爽了 | 国产偷人妻精品一区二区在线 | 波多野结衣一区二区小泽玛利亚一区二区 | 白嫩小泬BBB免费观看 | 久久国产乱子伦精品一区二区 | 日本中文字幕在线播放 | 黃色A片美女人20岁 肥老熟妇伦子伦456 | 亚洲国产精品狼友在线观看 | 精品人妻大屁股白浆无码 | 91在线无码精品秘 入口九色十 | 久久成人免费视频 | 国产又粗又猛又爽又黄 | 国产精品成人AAAAA网站 | 国产一区波多野结衣 | 国产裸体美女无遮挡永久免费 | 亚洲精品国产成人久久Av盗摄 | 国产一级a毛一级a视频 | BBBBXXⅩⅩ高清按摩 | 人妻在厨房被强乱到舒服 | 搡BBB搡BBB免费观看 | 蜜桃视频在线观看 91网 | 日本三级片免费看 | WWWWWWXXXXXX国产| 杨思敏黑人极品XXX 近親相姦中出中文字幕 | 乱老熟女一区二区三区 | 在线亚洲AV无码秘 蜜桃医院 |